Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures.
نویسندگان
چکیده
Sugiyama live attenuated measles vaccine produced in bovine renal ceIls was administered during pilot studies and a mass immunization programme in Iran. Clinical observations in several of the vaccinees revealed a mild fever lasting 3-4 days which was accompanicd by the appearance of a morbilIiform rash which faded in 2 days. There was no significant difference in rcactions from subcutaneous or intramuscular routes of inoculation. The mean of days of pyrexia was greater in plateau than in mountainous areas. The occurrence of a morbilIiform rash seemed to be higher in plateau than in mountainous regions especiaIly when vaccine was inoculated intramuscularly. When a doubledose of vaccine was administered, the adverse symptoms were more severe. The seroconversion was 95 to 100% ",hen specific antibodies were titrated by seroneutralization or by haemagglutination-inhibition tests.
منابع مشابه
Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures
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Efficacy and safety of live attenuated Sugiyama strain of measles virus in mass immunization of children in rural regions of Iran
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A New Field Trial with Two Types of Live Mealses Vaccine in Rural Regions of Iran(*)
Two further attenuated measles virus vaccines, Sugiyama and Aik strains, developed in baby calf kidney cells and in Human Diploid Cells (MRC5) respectively were compared in a field trial. Both vaccines showed c1inical evidence of attenuation and both were highly immunogenic. Problems related to the success and failure of mass immunization against measles in developing countries and in hot c1ima...
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Chapter 1 John F . Enders and Measles Virus Vaccine — a Reminiscence
Following their initial isolation in cell culture of the virus in 1954, a succession of investigators under the mentorship of John F. Enders conducted the research, development, and initial clinical studies responsible for the licensure in 1963 of a successful live attenuated measles virus vaccine. Propagation of the virus successively in human kidney cells, human amnion cells, embryonated hens...
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عنوان ژورنال:
- The Japanese journal of experimental medicine
دوره 41 1 شماره
صفحات -
تاریخ انتشار 1971